French President Emmanuel Macron has rejected the idea proposed by US President Donald Trump that the war criminal and Russian leader Vladimir Putin should be involved in mediation efforts between Israel and Iran.

Iran conflict could open opportunities for Russia to possibly become a power broker to help end the confrontation.

World leaders reacted to Israel’s strikes on Iran, with allies urging restraint and rivals condemning the escalation.

A new explosion was heard at a key uranium enrichment site in central Iran on Friday morning, hours after Israel launched unprecedented air strikes against the Islamic Republic's nuclear programme.

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