The Cardinals were "discombobulated" on the offensive end against the Razorbacks, and didn't have a physical edge on the defensive side.

Arkansas head coach John Calipari addressed the Razorback fanbase after beating Louisville, calling out a disrespectful “overrated” chant.

A dominant first half gave Arkansas basketball separartion, and the Razorbacks withstood Louisville's punches in the second period for an impressive home win.

LOUISVILLE, Ky. - The Louisville men's basketball program has run into their first true adversity of the you 2025-26 season. Tasked with facing Arkansas in Fayetteville for their leg of the ACC/SEC Challenge, the Cardinals could not come out of Bud Walton Arena with a win, dropping the ranked showdown 89-80 on Wednesday night.

Trevon Brazile scored 21 points to lead five Arkansas players in double figures as the 25th-ranked Razorbacks built a big lead and held off No. 6 Louisville 89-80.

The Louisville Cardinals tip off against the Arkansas Razorbacks at 7:15 p.m. ET Wednesday at Bud Walton Arena in Fayetteville, Arkansas.

No. 6 Louisville brings their perfect 7-0 record to Fayetteville as the Razorbacks look for their first ranked win of the season on ESPN.

Prior to Wednesday, the last game between the Razorbacks and the Cardinals was played at the 2022 Maui Invitational, an 80-54 victory by Arkansas over a Louisville team coached by Kenny Payne. Payne is in his second season as an assistant coach for the Razorbacks.

From the jump, Louisville seemed to struggle with Arkansas' length and athleticism, and even seemed to be rattled a bit. The Razorbacks scored the first six points of the game, and thanks to 14 points from Brazile in the first eight minutes, took a 23-17 lead over the first nine-plus minutes.

No. 6 Louisville men’s basketball picks up its first loss of the season at No. 25 Arkansas 89-80, in a game where Pat Kelsey’s Cards didn’t lead once. The Cardinals played catch-up over the course of the evening,