But Sunday was also the first game the Niners used Guerendo, their fourth-round pick in the 2024 draft and the fourth running back on the depth chart at the start of training camp, as the primary running back. And while he is no Christian McCaffrey, his skillset should demand a similar respect.

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey and talented backup Jordan Mason to serious injuries during the game. McCaffrey was subsequently placed on injured reserve,