The attack, which took place in the city of Palmyra, comes a year after the fall of Syrian President Bashar al-Assad and the lifting of U.S. sanctions.

Two U.S. soldiers and an interpreter were killed in an ambush by an apparent ISIS gunman in Syria Saturday, officials said.

Two soldiers and a civilian interpreter were killed while supporting counterterror operations, the Pentagon said. They are the first U.S. casualties in Syria since the fall of the dictator Bashar al-Assad.

US President Donald Trump has vowed retaliation after a suspected ISIS attack in Syria killed two American soldiers and a civilian interpreter near Palmyra, marking the deadliest assault on US personnel there since Bashar al-Assad’s fall.

There are many ISIS detainees in eastern Syria, including many families of ISIS fighters. These detainees will need to be addressed, and the families de-radicalized.

Over four days in late November 2025, U.S. and Syrian forces carried out a coordinated campaign that destroyed more than 15 ISIS weapons storage sites in southern Syria. The operation, conducted between November 24 and 27 in Rif Damashq province,

ERBIL, Kurdistan Region - The Syrian Democratic Forces (SDF) announced on Tuesday that their elite units captured an Islamic State (ISIS) “emir” during a raid conducted in cooperation with the US-led Global Coalition to Defeat ISIS in the eastern Deir ez-Zor province.