After injury, the long axonal projections of nerve cells are cut and "die-back" from the injury site, and at the same time, a ...

The most severe injuries have been associated with widespread axonal and myelin degeneration (Gentili, Hudson, and Hunter, 1980a). Pathological alterations in the nerve were evident as early as 30 ...

Repeated brain injury resulted in SOD1-ALS mice showing greater weight loss, an earlier tremor in the hind limbs, and ...

Melissa Jordan According to Johns Hopkins Medicine, a diffuse axonal injury (DAI) occurs when the brain's long nerve fibers (axons) are torn due to the brain shifting and rotating within the skull ...

This review considers the role that optic nerve head astrocytes might play in the initiation of axon damage, based on the hypothesis that these cells are sensitive to mechanical or ischaemic ...

Nerve-conduction abnormalities were present ... Some reduction in conduction velocity can be the result of axonal damage. Thus, the predominant pattern of neuropathy in our patients was of the ...

A team in Pittsburgh received a $2.3 million grant to fast-track the development and clinical transition of a minimally ...

the nerve fibers that allow for communication between different areas of the brain, there was significant degeneration, axonal and myelin loss, inflammation, and small blood vessel injury.

and by the reduction of the target-derived trophic factor nerve growth factor (NGF) all of which occur after transection of sympathetic axons. Strikingly, changes in these peptides occur in two other ...

Glaucoma is a complex and multifactorial neurodegenerative disorder primarily characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons, leading to irreversible visual ...

In the injured sciatic nerve they contribute to the process of Wallerian degeneration, the degradation and removal of axonal and myelin debris distal to the site of injury. In the dorsal root ganglia, ...