Researchers from The University of Texas MD Anderson Cancer Center identified a new role for heat shock protein 90 (HSP90) in ...

People inherit two copies of each gene - one from each parent - an evolutionary fail-safe to ensure survival even when one of them doesn't function. For cancer-suppressor genes like BRCA1, researchers ...

Researchers at the University of Cambridge have created the world's largest catalog of human breast cells, which has revealed early cell changes in healthy carriers of BRCA1 and BRCA2 gene mutations.

A study led by Harvard Medical School researchers shed new light on how even a single defective copy of the tumor-suppressor BRCA1 gene can increase patients’ risk of developing breast cancer.

University of Oregon biologists have uncovered a mechanism by which a well-known breast cancer gene also influences fertility. Mutations in the BRCA1 gene sharply increase a person’s risk of ...

NEW YORK (Reuters Health) - Among women with BRCA1 gene mutations, which are known to increase the risk of breast cancer, annual screening with both mammography and MRI is associated with better ...

Mutations in BRCA1 do not appear to contribute significantly to the risk of prostate cancer progression, according to DNA test results from 450 prostate cancer specimens. The findings suggest that ...

We applied the principle of synthetic lethality to discover a novel strategy for cancer treatment for patients with BRCA1 or ...

The authors do not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and have disclosed no relevant affiliations beyond their ...

BRCA gene expression is induced at the G1/S boundary in cultured cell lines (Gudas et al., 1996; Vaughn et al., 1996a,b) and primary tissues (Blackshear et al., 1998; Rajan et al., 1996), and the ...