Early findings showed EXG-34217 elongated telomere length ex vivo. The Food and Drug Administration (FDA) has granted Orphan Drug designation to EXG-34217 for the treatment of telomere biology ...

Researchers using a new method that handily lengthens human telomeres have found that treated cells act like young (untreated) cells, proliferating freely in the lab dish. The method entails using ...

Telomeres are repetitive sequences of DNA that can be found at the ends of chromosomes, where they form a kind of protective cap. Telomeres get shorter every time a cell divides, and they are thought ...

Aging affects everybody, so it’s easy to understand why so much scientific attention is focused on studying it. Scientists in Canada now claim to have found that telomeres play a different role in ...

This paper, published in December 1994, describes a polymerase chain reaction (PCR)-based assay for measuring the activity of telomerase, the enzyme that controls telomere length. But more important, ...

Long noncoding telomeric repeat–containing RNA (TERRA) has been implicated in telomere maintenance in a telomerase-dependent and a telomerase-independent manner during replicative senescence and ...

Cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging. UT Southwestern Medical Center cell ...

Recent progress in telomere research through new tools and assays may allow investigators to delve more deeply into the complicated mechanisms that control these key chromosomal structures. As ...

Researchers have further uncovered the secrets of telomeres, the caps that protect the ends of our chromosomes. They discovered that an RNA molecule called TERRA helps to ensure that very short (or ...

Edited by: Karen Young Kreeger C.M. Counter, J. Gupta, C.B. Harley, B. Leber, S. Bacchetti, "Telomerase activity in normal leukocytes and hematologic malignancies ...