Epigenetic mapping provides deeper insight into leukemia

Researchers at Karolinska Institutet in Sweden and Kyoto University in Japan have identified new subgroups of the blood ...
Medical Xpress

Single-cell atlas reveals hidden patterns of differentiation in acute myeloid leukemia

In the study, "Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation," published in Blood Cancer Discovery, ...
The Scientist

Final Destination: Distinct Cell Differentiation Patterns in Acute Myeloid Leukemia Revealed

A comprehensive map of aberrant hematopoiesis in people with acute myeloid leukemia defines specific cell states and potential therapeutic targets. The team used their reference map for normal ...
EurekAlert!

Mapping the bone marrow T-cell atlas in CML patients

Chronic myeloid leukemia (CML) is a hematopoietic malignancy characterized by BCR-ABL1 gene fusion. The immune microenvironment, implicated in relapse and drug resistance, poses significant challenges ...
Science Daily

Rapid growth of blood cancer driven by a single genetic 'hit'

Chronic myeloid leukemia may seem to appear suddenly, but new research shows it begins years before diagnosis with an explosive surge of growth. Scientists tracked how a single genetic accident—the ...
The American Journal of Managed Care

Inside the Discovery That Changed CML Treatment Forever: Jorge Cortes, MD

Lead CML researcher discusses the evolution of a groundbreaking treatment and its effect on patient survival. When imatinib (Gleevec; Novartis), the first-ever tyrosine kinase inhibitor, made its ...