Ovarian cancer cells frequently demonstrate resistance to apoptosis-inducing chemotherapy. The unfortunate consequence is relapse with incurable disease in over half of the women diagnosed with this ...

Excessive alcohol consumption is the primary cause of chronic liver disease and liver-related mortality in Western countries. According to the report of the World Health Organization (WHO), ...

This is a preview. Log in through your library . Abstract Missense mutation in the proline-serine-threonine phosphataseinteracting protein 2 (Pstpip2) gene results in the development of spontaneous ...

The caspase-8 gene plays a critical role in suppressing metastasis (spread) of neuroblastoma, and the expression of this gene is frequently absent in cancer cells that are aggressively metastasizing, ...

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard ...

DUBLIN--(BUSINESS WIRE)--The "Caspase 8 - Pipeline Review, H2 2018" drug pipelines has been added to ResearchAndMarkets.com's offering. Caspase 8 (Apoptotic Cysteine Protease or Apoptotic Protease Mch ...

Myocardial ischemic disease is the major cause of death worldwide. After myocardial infarction, reperfusion of infracted heart has been an important objective of strategies to improve outcomes.

Most cases of autoimmune lymphoproliferative syndrome (ALPS) are associated with heterozygous mutations in the genes encoding CD95 (Fas receptor), CD95 ligand and the apoptotic enzyme caspase-10.

MIB2 constitutively binds and ubiquitylates cFLIP. Upon TNF stimulation, caspase 8 and ubiquitylated cFLIP are recruited to the death-inducing complex. Ubiquitylated cFLIP prevents a proper oligomer ...