A retrospective study evaluates the effectiveness of CD19 CAR T-cell therapy in relapsed/refractory B-cell acute lymphoblastic leukemia with extramedullary or CNS disease.

The treatment showed effectiveness in achieving local control of acute myeloid leukemia (AML) that developed in the eyes of a pediatric patient. When AML is present outside of the bone marrow and ...

Outcomes were worse for patients with multiple myeloma (MM) and extramedullary disease, and the authors said their findings indicate that evaluation of extramedullary response using imaging is needed ...

Extramedullary plasmacytoma is a plasma cell tumor that develops outside the bone marrow. These plasmacytomas commonly occur in the head and neck region, particularly in the upper respiratory and ...

In 1962, Pitcock et al 12 published their findings in adults with myelofibrosis. Renal extramedullary hematopoiesis was recognized in 35% of autopsies. In this series of 17 complete autopsies, the ...

TWO patients seen during the past ten years have justified a re-emphasis of the fact that paravertebral masses of hemopoietic tissue in the thorax can develop in hereditary spherocytic anemia. In the ...

Patients with plasmacytomas that are noncontiguous with bone marrow (true extramedullary myeloma) are at high risk for disease progression or relapse. Phase 1 of the RedirecTT-1 study showed promising ...

Associations of T-cell fitness prior to B-cell maturation antigen (BCMA)–targeted chimeric antigen receptor T-cell (CART) and bispecific T-cell engager (BiTE) therapies and efficacy/toxicity in ...

Extramedullary myeloma is an aggressive form of the disease with median survival at around five months. A new treatment combining two drugs dramatically delayed progression of the disease and improved ...

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