Head and neck cancer remains a major global health challenge, ranking among the six most common cancers worldwide and claiming hundreds of thousands of lives each year. A growing body of evidence now ...
Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...
Metabolic reprogramming in neuroinflammation refers to dynamic shifts in cellular energy pathways that underpin the activation, function and fate of central nervous system immune cells, principally ...
Tumor-associated macrophages (TAMs) are immune cells that tumors hijack to fuel their own growth and evade immune attack. A comprehensive new review ...
Why do some of the most advanced cancer therapies fail against solid tumors? Despite remarkable success in blood cancers, CAR-T cell treatment is much less effective against solid tumors due to the ...
Breast cancer development is not solely the result of cancer cells acting independently, it involves a dynamic and complex ecosystem composed of cancer cells, immune cells, fibroblasts, adipocytes, ...
Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, CD8⁺ T-cell exhaustion, EMT, and fibrosis that reinforce immune-protected ...
Significant opportunities in the cancer metabolism-based therapeutics market include leveraging precision medicine to target unique cancer cell metabolic pathways, driving personalized treatment ...
Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center ...
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