The mevalonate pathway is central to the biosynthesis of isoprenoids and sterols, underpinning a range of essential cellular processes. Farnesyl diphosphate synthase (FPPS) is a pivotal enzyme in this ...

Among 312,907 identified patients with cancer, treatment groups included statin users (n = 65,440), nonstatin users who received medications that block cholesterol absorption (n = 9,289), and nonusers ...

The earty morphogenetic mechanisms involved in heart formation are evolutionarily conserved. A screen for genes that control Drosophila heart development revealed a cardiac defect in which pericardial ...

Researchers showed that the mevalonate pathway is essential for embryonic development by promoting primitive streak formation, a key landmark for establishing embryo symmetry and gastrulation. The ...

Masashi Suzuki, Shoko Nakagawa, Yukiko Kamide, Keiko Kobayashi, Kiyoshi Ohyama, Hiromi Hashinokuchi, Reiko Kiuchi, Kazuki Saito, Toshiya Muranaka, Noriko Nagata Journal of Experimental Botany, Vol. 60 ...

Schematic diagram of mouse embryonic development on the indicated days. Bottom: The mevalonate pathway produces farnesyl diphosphate for cholesterol synthesis, protein geranylgeranylation and protein ...

A metabolic pathway that is up-regulated in some breast cancers promotes the disease's progression by activating a signaling protein called Arf6, according to a paper. The study suggests that ...

Artemisia annua is celebrated for its production of artemisinin, a powerful antimalarial agent. Although its glandular secretory trichomes have been the focus of extensive research, a complete ...

Long-held dogma says lung fibrosis in diseases like idiopathic pulmonary fibrosis, or IPF, results from recurrent injury to alveolar epithelium that is followed by dysregulated repair. Research at the ...

Cohort studies report associations between statin use and improved survival in patients with cancer. We used pharmacoepidemiologic methods to evaluate the survival of patients with cancer who received ...