Highlights from the Week 10 matchup between the Los Angeles Rams and the San Francisco 49ers during the 2025 NFL season.

The Los Angeles Rams were in Santa Clara today for their second meeting with the San Francisco 49ers, a rematch of their Week 5 showdown. The Rams were seeking their fourth straight victory since that loss to the 49ers, playing like one of the best teams in the league.

The Rams' quarterback had a stellar performance on Sunday, throwing for 280 yards and four touchdowns in their 42-26 win over the 49ers. His second touchdown pass of the day gave him 400 passing touchdowns in his career, making Stafford just the ninth quarterback in NFL history to reach that threshold.

The San Francisco 49ers stayed atop the NFC West with a miracle win over the Los Angeles Rams in Week 5. Here are the highlights.

The Atlanta Falcons were defeated by the San Francisco 49ers to fall to 3-3 on the season. Despite a solid effort, the Falcons made too many critical errors against a good 49ers team on the road, losing by a final score of 20-10. Atlanta committed costly penalties and failed to score when they had the chance on multiple drives.

Matthew Stafford connected with Puka Nacua for a 22-yard TD, extending the Los Angeles Rams' lead over the San Francisco 49ers.

NFL highlights of the Rams dominating the 49ers, led by Matthew Stafford, Davante Adams, and Kyren Williams. The Rams offense was on fire!

Before we look ahead of to Week 8, though, let's recap what happened in the Falcons ' 20-10 loss to the 49ers. Atlanta controlled the game in the first half before making some crucial mistakes late in the first half that cost the team points and gave the 49ers life.

The San Francisco 49ers suffered another major setback on Sunday, falling 42-26 to the Los Angeles Rams at Levi's Stadium. It marked their fourth loss in the past seven games — and their first against an NFC West rival this season.