We sought to isolate the stem clone, as it was most likely to have the ability to acquire additional translocations with further propagation in vitro. After subcloning, the signature karyotype of the ...

STRUCTURAL heterozygosis is the existence in heterozygous state of an interchromosomal or intrachromosomal rearrangement. Fragmentation of two chromosomes and the mutual exchange through reunion of ...

Chromosome translocations are relatively common in humans. They result from the exchange between nonhomologous autosomes. Approximately one couple out of 600 carries a reciprocal translocation [1].

The earliest indication of the pervasive role of genomic alterations in acute myeloid leukemia (AML) came from identification of recurrent, nonrandom karyotypic alterations nearly 40 years ago. The ...

When we think of parasites, we picture ticks or worms. But lurking inside our own genomes are far stealthier hitchhikers: jumping fragments of human DNA that behave like genetic parasites and can ...