The heterotrimeric synaptic soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, consisting of the synaptic vesicle-associated membrane protein 2 (VAMP2) and ...

Assembly of the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) complex is an essential step for neurotransmitter release in synapses. The presynaptic plasma membrane ...

Munc18-1 and Syntaxin1 are essential proteins for SNARE-mediated neurotransmission. Munc18-1 participates in synaptic vesicle fusion via dual roles: as a docking/chaperone protein by binding closed ...

The peptide commonly referred to as SNAP-8 (acetyl octapeptide-3) is a synthetic fragment derivative of SNAP-25, engineered ...

To release neurotransmitters, nerve terminals must repeatedly break down and rebuild specialized protein complexes, and the fidelity of this process may rely on α-synuclein, a protein that misfolds in ...

KAIST researchers discovered that NSF unravels a single SNARE complex using one round ATP turnover by tearing the complex with a single burst, contradicting a previous theory that it unwinds in a ...

Vesicle fusion in eukaryotes is thought to involve the assembly of a highly conserved family of proteins termed soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) into a ...

The chaperone Hsc70 (green) helps keep SNAP-25 in the proper shape so that it can help form the SNARE complex, enabling neurotransmission. AMHERST, Mass. – A team of researchers from the University of ...

SNARE proteins are a large protein superfamily consisting of more than 60 members in yeast and mammals. The primary role of these proteins is to mediate fusion of vesicles with their target membrane ...

In 2013, James E. Rothman, Randy W. Schekman, and Thomas C. Südhof won the Nobel Prize in Physiology or Medicine for their discoveries of molecular machineries for vesicle trafficking, a major ...

In 2013, James E. Rothman, Randy W. Schekman, and Thomas C. Südhof won the Nobel Prize in Physiology or Medicine for their discoveries of molecular machineries for vesicle trafficking, a major ...