Alzheimer’s may destroy memory by flipping a single molecular switch that tells neurons to prune their own connections. Researchers found that both amyloid beta and inflammation converge on the same ...

For more than a century, the story of the brain has been told as a tale of neurons, with every thought and memory traced to their electrical chatter. That narrative is now being rewritten as evidence ...

A study maps how toxic tau disrupts synapses over time, showing early postsynaptic damage that later spreads presynaptically.

Co-written with Jai Liester. Silent synapses represent one of neuroscience's most fascinating discoveries—connections between neurons that lie dormant until activated by specific triggers. These ...

A study published in Science Advances led by researchers at the University of Alabama at Birmingham and Rush University Medical Center, Chicago, Illinois, now provides evidence that the preservation ...

Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia. How this happens remains largely ...

(Nanowerk Spotlight) The human brain processes complex information while consuming merely the power of a dim light bulb. This remarkable efficiency stems from synapses, the connections between brain ...

Johns Hopkins scientists reveal that “inactive” GluD brain proteins regulate neuronal communication and open up new ...

By simply "sprinkling" this probe on top, active synapses will visibly light up so that researchers can clearly observe how living brain cells communicate—all within 10 seconds. This research gives us ...

Scientists at Johns Hopkins have uncovered a surprising new way to influence brain activity by targeting a long-mysterious class of proteins linked to anxiety, schizophrenia, and movement disorders.

Instant synapse visualization with our fluorescence probe. A diagram showing that the fluorescent probe can visualize AMPA receptors on synapses by sprinkling. There are few scientific methods more ...