In a new study, scientists have identified a small molecule candidate drug that triggers the formation of left-handed Z-DNA in cells that in turn activates a highly immunogenic programmed pathway of ...
In 1979, Alexander Rich, PhD, and his colleagues solved the structure of a self-complementary DNA hexamer and discovered that the molecule formed a left-handed double helix (Z-DNA). (Credit: Journal ...
Approximately 13% of the human genome at certain motifs have the potential to form non-canonical (non-B) DNA structures (e.g. G-quadruplexes, cruciforms, and Z-DNA), which regulate many cellular ...
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