Hosted by Conan O’Brien and broadcast live on ABC and Hulu, the ceremony’s Best Actress category has emerged as a nail-biter. Demi Moore (The Substance) and Mikey Madison (Anora) lead the pack, but the race remains fluid as voters weigh career-defining narratives against breakout potential.

Demi Moore, a 2025 Oscar nominee for Best Actress, shares daughters Rumer Willis, Scout Willis and Tallulah Willis with ex Bruce Willis—and she shows up for his wife Emma Heming and their two kids.

In the coming-of-age film, "Now and Then," Moore played the older version of a young girl named Samantha, who together with her friends, played by Rosie O'Donnell, Rita Wilson and Melanie Griffith, recall a memorable summer they shared in 1970.