The discovery five years ago that short interfering RNAs (siRNAs) can also silence gene expression in higher organisms has revolutionized loss-of-function genetic screens in mammalian cells 1. The use ...
Cell therapy developer Celyad Oncology is using short-hairpin RNA (shRNA) to create T cells that can be used as an “off-the-shelf” allogeneic therapy for cancer patients. They are also using the ...
RNA-based therapies are enjoying a renaissance, owing in part to the recent approvals of Alnylam Pharmaceuticals’ RNA interference (RNAi) drugs, Onpattro ® (patisiran) and Givlaari™ (givosiran).
RNA interference is a biological process that has evolved with the evolution of mammals and plays an important role in transient and long-term blocking of protein expression. Short Hairpin RNA (shRNA) ...
An increase in serum choline levels to predict progression-free survival (PFS) in patients (pts) with advanced cancers receiving pembrolizumab. A phase I, dose-escalation study of ADG106, a fully ...
Development of prognostic molecular markers in pediatric rhabdomyosarcoma based on gene expression and copy number variations. Evaluation of the effect of care at NCI comprehensive cancer centers ...
Previous studies have indicated that the heparanase (HPA) is correlated with histopathological parameters and poor prognosis of gastric cancers. Although their efficiencies in inhibiting the ...
MONT-SAINT-GUIBERT, Belgium--(BUSINESS WIRE)--Regulatory News: Celyad Oncology SA (Euronext & Nasdaq: CYAD) (Brussels:CYAD) (Paris:CYAD) (NASDAQ:CYAD) (Celyad Oncology or the Company), a ...
If our TRC library does not cover the hairpin you need for your research, we can clone a custom sequence for you into the TRC library vector pLKO.1. Contact us by email if you wish to order custom ...
Shortly after the cellular mechanism of RNA interference (RNAi) was first described, scientists began utilizing this powerful technique to study gene function. The most effective way to alter a gene’s ...
What is Short Hairpin RNA? RNA serves a wide variety of roles within a cell, carrying out catalytic, regulatory, structural and genetic transferal functions. A type of artificial RNA, called short ...
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