The major finding presented here is that antipsychotics activated SMAD3, a downstream effector of TGFβ signaling, through a non-canonical pathway that involves neither the TGFβ receptor complex ...

In the reviews presented here, the authors bring their unique perspective to describe the possible mechanisms by which signaling pathways regulated by G protein coupled receptors and G proteins ...

Direct KRAS Effector Pathways Involved in Cell Transformation & Lung Tumorigenesis KRAS activates signaling downstream of the RAF, PI3K and RAL pathways, which have been firmly established as ...

TNF-α probably represents a common effector pathway that acts downstream in the inflammatory process (Figure 2).

Sweet taste receptors in the heart: A new pathway for cardiac regulation New research shows that the heart can sense sweeteners and can increase the force of heart muscle contraction in response ...

These experiments establish the central role of FRS2α in signaling via FGFRs and demonstrate that FRS2α mediates multiple FGFR-dependent signaling pathways critical for embryonic development. PNAS is ...

KY1044 to target the ICOS pathways inducing intratumoral Treg depletion and agonism of effector T cells: Preliminary pharmacodynamic markers from a phase 1/2 multicenter trial.

Christian Posch, Homayoun Moslehi, Luzviminda Feeney, Gary A. Green, Anoosheh Ebaee, Valentin Feichtenschlager, Kim Chong, Lily Peng, Michelle T. Dimon, Thomas Phillips, Adil I. Daud, Timothy H.

Study: An anti-SARS-CoV-2 non-neutralizing antibody with Fc-effector function defines a new NTD epitope and delays neuroinvasion and death in K18-hACE2 mice. Image Credit: ktsdesign / Shutterstock ...

Partnering with VantAI could give Halda a source of target-effector pairs for its next wave of prospects. The deal could be ...

ROCKVILLE, MD – In a surprising discovery, scientists have found that the heart possesses "sweet taste" receptors, similar to those on our tongues, and that stimulating these receptors with ...

In a surprising discovery, scientists have found that the heart possesses "sweet taste" receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can ...