Gut

Does a long time to colonoscopy after a positive faecal immunochemical test result have a deleterious impact on colorectal cancer outcomes? A nationwide cohort study

Background Depending on the colorectal cancer (CRC) screening programme, a colonoscopy should be performed within 1–3 months ...
Gut

Acute upper gastrointestinal bleeding in the UK: 2022 audit update

Background Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency with evolving demographics and ...
Gut

FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis

Background Eosinophilic oesophagitis (EoE) is a chronic allergic disease characterised by oesophageal epithelial remodelling, barrier dysfunction and inflammation. The transcription factor forkhead ...
Gut

Discovery of a carboxyl fullerene derivative as a new lipid droplet regulator inhibiting MASLD

Background The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly increasing with high ...
gut.bmj

High-protein diets alleviate tumour growth and drug resistance by promoting AKT aggregation and turnover

Background Despite the long-standing recommendations of high-protein diets for patients with cancer, the precise mechanisms of this dietary approach in benefiting tumour suppression and enhancing ...
gut.bmj

Non-invasive tests of fibrosis in the management of MASLD: revolutionising diagnosis, progression and regression monitoring

4 State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China With the recent conditional approval of resmetirom by the US Food and ...
gut.bmj

Combination of carvedilol with variceal band ligation in prevention of first variceal bleed in Child-Turcotte-Pugh B and C cirrhosis with high-risk oesophageal varices: the ...

Correspondence to Professor Shiv Kumar Sarin, Hepatology, Institute of Liver and Biliary Sciences, New Delhi, Delhi 110070, India; shivsarin{at}gmail.com Objectives Beta-blockers and endoscopic ...
gut.bmj

Faecal calprotectin indicates intestinal inflammation in COVID-19

Correspondence to Professor Herbert Tilg, Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University Innsbruck, Innsbruck 6020, Austria; ...
gut.bmj

Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer

Correspondence to Dr Yanlei Ma, Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; yanleima{at}fudan.edu.cn Objective The incidence of early-onset ...
gut.bmj

Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis

1 State Key Laboratory of Systems Medicine for Cancer; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health; Division of Gastroenterology and Hepatology; Shanghai Cancer Institute; ...
gut.bmj

Complete and incomplete intestinal metaplasia at the oesophagogastric junction: prevalences and associations with endoscopic erosive oesophagitis and gastritis

BACKGROUND/AIMS Intestinal metaplasia (IM) is a common finding at the oesophagogastric junction, but the aetiopathogenesis of the different IM subtypes—that is, incomplete IM (specialised columnar ...
gut.bmj

Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease

Professor J P Galmiche, Centre de Recherche en Nutrition Humaine, CRI INSERM 95-08, CHU, Hôtel Dieu, Place A Ricordeau, 44035 Nantes cedex 01, France. Email:galmiche{at}easynet.fr BACKGROUND/AIM ...