Two defensive stars were lost for the season. Their QB missed multiple games. Still, here are the 49ers are, a game out of the No. 1 seed.

NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers and Indianapolis Colts.

Despite losing to the Seattle Seahawks on Sunday in his first start since the 2020 season, Indianapolis Colts veteran quarterback Philip Rivers will get his chance at redemption.

After starting the season with a 10-4 record, the San Francisco 49ers take on the Indianapolis. Here's a look at the betting odds for the matchup.

Indianapolis Colts' head coach Shane Steichen confirmed on Monday that Phillip Rivers will start in next week's game against the San Francisco 49ers on Monday Night football. This announcement by Steichen doesn't come as a surprise. In Rivers' return to action against Seattle, he provided needed stability at the quarterback position.

The 49ers' offense is about the same as 2024. The defense is worse. The special teams, though, has taken a historic leap. Is it sustainable?

On "49ers Now," Carlos Ramirez, Rod Brooks and Jennifer Lee Chan break down NBC Sports Bay Area's Week 16 NFL Power Rankings.49ers Now: Breaking down NFL Power Rankings entering Week 16 as playoffs ne

Things are looking good in terms of injuries for the 49ers coming out of a 37-24 win over the Tennessee Titans, but the status of wide receiver Ricky Pearsall Jr. won’t be known until later