The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

San Francisco 49ers running back Isaac Guerendo discussed being the "next man up" with Christian McCaffrey and Jordan Mason expected to miss significant time due to injury.

San Francisco 49ers linebacker Fred Warner recently revealed that he has been playing through a bone fracture in his ankle, ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Join Packers Head Coach Matt LaFleur and analyst Larry McCarren as they recap the Packers' Week 13 win over Miami and preview ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

The Green Bay Packers have made their injury decisions about wide receiver Romeo Doubs and three others ahead of Week 12's ...

One NFL source suggests that the Chicago Bears pull off a blockbuster trade for their next head coach in 2025.

ProFootballTalk founder Mike Florio has an intriguing idea for a change of scenery for Kyle Shanahan. Appearing on “The Rich ...