Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

Following their win over the San Francisco 49ers, the Bills (10-2) will take on the Los Angeles Rams (6-6) at SoFi Stadium in ...

ET on Sunday, the Chicago Bears play at the San Francisco 49ers.In their last outing, the 49ers lost 35-10 to the Buffalo ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

While the Chicago Bears are reeling in a six-game losing streak and having just fired their head coach, the San Francisco ...

We've reached crunch time in the playoff chase, with plenty of teams pursuing a postseason place in Week 14 of the NFL.

McCaffrey's post garnered all sorts of reactions from fans and NFL personalities alike. One that stood out, however, is his wife Olivia Culpo's five-word message for her husband, who is clearly going ...

Isaac Guerendo will make his first NFL start on Sunday as the injury-depleted San Francisco 49ers face the Chicago Bears. The ...

The San Francisco 49ers on Wednesday continued adjusting to life without running backs Christian McCaffrey and Jordan Mason.

What has to be done for the San Francisco 49ers to have a chance at the playoffs or at the very least, a winning season in ...

Get the latest NFL Week 15 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on ...