Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

San Francisco 49ers defensive end Nick Bosa (hip/oblique) missed his second contest in a row due to hip and oblique injuries.

Sunday night as snow fell throughout Buffalo’s Week 13 home game against San Francisco. For the Bills, the conditions were ...

There's even a chance Guerendo, who pulled his hamstring on the first day of training camp and missed the first two preseason ...

San Francisco 49ers coach Kyle Shanahan is sharing an update on Trent Williams and his family after the left tackle's son was ...

The Bills are a Super Bowl contender and the 49ers somehow probably aren’t even a playoff team. That’s how Sunday night’s ...

The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

Just about this time of the year it seems the University of Washington football team takes something away from Steve ...

Sondra Williams, the wife of San Francisco 49ers tackle Trent Williams, said on social media that their son, Trenton, was ...

The Buffalo Bills easily got past the San Francisco 49ers 35-10 on a snowy Sunday Night Football matchup. Here are winners ...

Holmgren coached at three Bay Area high schools and San Francisco State before climbing to the NFL ranks, where he won two ...

The 49ers' disappointing season took another negative turn in their Week 13 loss to the Bills, and George Kittle addressed ...