The Chicago Cubs (60-42) visit the South Side of Chicago to face the Chicago White Sox (37-66) Friday in the first game of a 3-game interleague series. First pitch from Rate Field is at 7:40 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Cubs vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Our Cubs vs. White Sox predictions believe Shota Imanaga will shut down the South Siders' lineup on Friday, July 25, 2025.

The Under is 2-0-1 in the last 3 matchups between the Red Sox and Cubs. Boston has been trending low, with the Under hitting in 5 of its last 6 games. Chicago has also leaned Under, going 6-1-1 in its last 8 contests. With Crochet on the mound, the Under has cashed in 4 of his last 6 starts. Stick with the trend.