Christian McCaffrey's injury against the Bills could be due to the heavy workload he received since returning to the 49ers.

During a segment of "Good Morning Football", NFL Network Insider Ian Rapoport elaborates on the severity of the injury report ...

NFL Network's Akbar Gbajabiamila shares the NFL Way to Play Week 13 winners. NFL Network's Kyle Brandt crowns Week 13 angry ...

49ers head coach Kyle Shanahan told reporters Monday that McCaffrey suffered a posterior cruciate ligament (PCL) injury ...

The San Francisco 49ers are preparing for rookie running back Isaac Guerendo to take on the primary ball-carrying duties for ...

Rookie fourth-round pick Isaac Guerendo seemed to be an afterthought in the San Francisco 49ers backfield with Christian ...

NFL Week 14 waiver wire cheat sheet for all league sizes and formats, with players you need to add, drop and stream in your ...

The 49ers have lost three games in a row, but their season isn't dead yet. Sure, they're in last place in the NFC West, but ...

The San Francisco 49ers and fantasy football players who were relying on the NFC West team's running backs are probably all ...

The 2024 season has been a renaissance for running backs. After years of toiling away on middling teams, Philadelphia Eagles ...

The San Francisco 49ers and Chicago Bears entered the 2024 NFL season full of hope. While the former eyed another trip to the ...

The San Francisco 49ers' brutal battle against the injury bug continues to get worse, as they have lost their two main running backs — Christian ...