Sen. Lindsey Graham told CBS's "Face The Nation" that he urges President Trump to be prepared to join Israel's attack on Iran up to and including "regime change," if a single American is targeted by Iran.

Israel had a plan to assassinate Iranian Supreme Leader Ayatollah Ali Khamenei, but President Trump vetoed the operation, according to reports.

The conflict, the most intense fighting between the two countries in decades, has been met in the United States with feelings of “frustration and helplessness,” as well as heartbreak.

Israeli Prime Minister Benjamin Netanyahu discusses why Israel carried out their strikes on Iran’s nuclear facilities, intel shared with the United States and more on ‘Special Report.’

Countries trade strikes as tensions grow over larger Middle East conflict - Iranian missiles struck an apartment building in the Galilee region, killing four people, as the countries exchanged fire

The United States is the main international backer of Israel, Iran's biggest regional foe. It is also a close ally of Sunni Gulf monarchies which for years pursued their own rivalry with the Islamic Republic, seeing it as their main regional threat.

Iran launched multiple deadly waves of missiles and drones toward Israel into Saturday morning following Israel’s unprecedented strikes aimed at destroying Iran’s nuclear program and decapitating its military leadership.

Iranian officials said on Friday that the United States "shall be held fully accountable" for its support of Israel after the nation took out key Iranian nuclear facilities and killed government leaders in a series of air strikes this week.