Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

Williams’ wife, Sondra, announced on Instagram on Sunday, Dec. 1 that their son Trenton O'Brien Williams Jr. was stillborn on ...

Kyle Shanahan can no longer save the San Francisco 49ers. We have reached the month of December and quite the time in the NFL ...

Sondra Williams, the wife of San Francisco 49ers tackle Trent Williams, said on social media that their son, Trenton, was ...

Josh Allen expertly navigated snow-topped turf, finding the end zone in a multitude of fashions and even receiving credit for ...

Sondra Williams, the wife of San Francisco 49ers left tackle Trent Williams, announced Monday that the couple had a son, ...

The 49ers opened the practice window for safety Talanoa Hufanga, who has missed the last seven games with a wrist injury.

San Francisco 49ers star running back Christian McCaffrey will not need surgery on his injured right knee but will miss the ...

San Francisco 49ers coach Kyle Shanahan is sharing an update on Trent Williams and his family after the left tackle's son was ...

The San Francisco 49ers on Wednesday began their week of practice as they gear up for what amounts to a season-ending stretch ...