Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

San Francisco 49ers coach Kyle Shanahan is sharing an update on Trent Williams and his family after the left tackle's son was ...

How to watch Sunday's Bears and 49ers game with betting lines and trends and radio information as Caleb Williams and Co. try ...

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

San Francisco 49ers' Trent Williams' wife Sondra has announced the death of their baby son at 35 weeks after losing his twin ...

Sondra Williams, the wife of San Francisco 49ers tackle Trent Williams, said on social media that their son, Trenton, was ...

Williams’ wife, Sondra, announced on Instagram on Sunday, Dec. 1 that their son Trenton O'Brien Williams Jr. was stillborn on ...

San Francisco 49ers star running back Christian McCaffrey will not need surgery on his injured right knee but will miss the ...

Buffalo (9-2) brings a six-game winning streak into a matchup with San Francisco (5-6) on Sunday, December 1, 2024 at ...

It's the Bills vs the 49ers in Week 13 of the 2024 NFL season. Here's how to watch, including time, channel, TV schedule and ...

After Trent Williams and wife Sondra shared the devastating loss of their son Trenton O'Brien Williams Jr. from a stillbirth, ...