With its 35-10 loss at Buffalo on Sunday night, the 49ers have now dropped three straight to sink to 5-7 on the season. The blowout loss also marked the first time since 2015 and just the fourth time in franchise history that San Francisco has lost back-to-back games by 25 points or more.

San Francisco 49ers running back Jordan Mason is going on injured reserve, head coach Kyle Shanahan announced.

The San Francisco 49ers running back injured the PCL in his knee, an MRI confirmed Monday. San Francisco plans to place McCaffrey on injured reserve. He is expected to miss six weeks. Head coach Kyle Shanahan announced the news during his Monday press conference.

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and San Francisco 49ers.

Patrick Everson breaks down the football weekend that was, including how the 49ers' struggles impacted the books, and some mixed reactions after UM stunned Ohio State.

San Francisco 49ers running back Christian McCaffrey will not need surgery on his injured right knee but he will miss the rest of the regular season.

The 49ers — who were already without Trent Williams, Nick Bosa and Deommodore Lenoir — saw Christian McCaffrey leave their blowout Sunday night loss to Buffalo early after a non-contact injury that didn't look good.

The Miami Dolphins' Week 16 matchup against the San Francisco 49ers at Hard Rock Stadium is losing luster by the minute. What had the makings of a showdown betw

We're live with the Week 13 edition of "Sunday Night Football" as the Buffalo Bills play host to the San Francisco 49ers to cap what has been a wild Thanksgiving weekend of NFL games. San Francisco enters this game incredibly banged up,

The San Francisco 49ers make the trip to snowy Buffalo, NY to face Josh Allen and the Buffalo Bills on Sunday Night Football.

The 2024 NFL Week 13 games end with Sunday Night Football as the Buffalo Bills host the San Francisco 49ers. NFL TV schedule, time and how to watch.