There's even a chance Guerendo, who pulled his hamstring on the first day of training camp and missed the first two preseason games, could return kicks for the Niners as he took a kickoff back 93 yards in the 49ers' preseason finale.

Holmgren coached at three Bay Area high schools and San Francisco State before climbing to the NFL ranks, where he won two Super Bowls as a 49ers assistant and another as the coach of the Packers.

Has the sun officially set on the 49ers? Let's look closer at San Francisco's lost season, Arthur Smith's rising offense in Pittsburgh and big Week 13 trends.

With its 35-10 loss at Buffalo on Sunday night, the 49ers have now dropped three straight to sink to 5-7 on the season. The blowout loss also marked the first time since 2015 and just the fourth time in franchise history that San Francisco has lost back-to-back games by 25 points or more.

The San Francisco 49ers make the trip to snowy Buffalo, NY to face Josh Allen and the Buffalo Bills on Sunday Night Football.

NFL Week 13 closes with Sunday Night Football as the San Francisco 49ers visit Highmark Stadium and the Buffalo Bills. Time and how to watch.

San Francisco was without starting quarterback Brock Purdy (shoulder ... How should you approach Purdy with your Bills vs. 49ers NFL DFS picks? The 49ers have been decimated by injuries throughout the season, and they are facing a Buffalo team that ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and San Francisco 49ers.

Sunday Night Football prop picks and NFL SGP for San Francisco 49ers vs. Buffalo Bills for sites like PrizePicks, Underdog Fantasy, DraftKings, Pick6, and more