San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

The San Francisco 49ers are currently in last place in the division and in danger of missing the playoffs. The 49ers have ...

The San Francisco 49ers are currently in last place in the division and in danger of missing the playoffs. Looking ahead, ...

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

The San Francisco 49ers on Wednesday continued adjusting to life without running backs Christian McCaffrey and Jordan Mason.

See who's in and who's out for the Week 14 matchup between the San Francisco 49ers and Chicago Bears on December 8, 2024.

The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

A spate of injuries has derailed the 49ers' Super Bowl hopes his season, but the bigger question is if their title window has ...