San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Wednesday practice report is starting to have two constants for the San Francisco 49ers. Those two constants are star players ...

The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

The San Francisco 49ers are currently in last place in the division and in danger of missing the playoffs. The 49ers have ...

The San Francisco 49ers are currently in last place in the division and in danger of missing the playoffs. Looking ahead, ...

See who's in and who's out for the Week 14 matchup between the San Francisco 49ers and Chicago Bears on December 8, 2024.

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

The San Francisco 49ers on Wednesday continued adjusting to life without running backs Christian McCaffrey and Jordan Mason.