Miami leads the all-time series with a 12-4-1 record, though Mario Cristobal and Jeff Brohm have split their meetings since taking over as head coaches at their respective alma maters. Louisville won 38-31 in 2023 en route to locking up a spot in the ACC title game, then last season Miami got revenge with a 52-45 win in Louisville last year.

Louisville has a long history of high-powered offense. Coach Jeff Brohm has a much more balanced group of Cardinals these days.

As for Miami, they haven't been hit nearly as hard by the injury bug. While defensive lineman Hayden Lowe continues to be out, the Canes did get running back Jordan Lyle and wide receiver Joshua Trader back for their last game at Florida State. Not to mention they are also coming off of a bye week.

Who will be out for Louisville football in the Cards' road game against Miami? Here's the latest injury report.

The No. 2 Miami Hurricanes have a relatively clean bill of health entering their home game against the Louisville Cardinals on Friday.

It wouldn't be the first time Brohm has utilized multiple quarterbacks at Louisville. In 2004 as the quarterbacks coach under then-head coach Bobby Petrino, the Cardinals ran a two-quarterback system between senior Stefan LeFors and highly-touted true freshman (plus little brother and current quarterbacks coach/offensive coordinator) Brian Brohm.

Moss, to his credit, has kept the offense afloat – though he also has sprung the occasional costly leak. He threw for 329 yards and two touchdowns last week. Chris Bell has 305 yards and three touchdowns in the last two games and leads the ACC in making defensive backs feel bad about themselves.