eLife

Using step selection functions to analyse human mobility using telemetry data in infectious disease epidemiology: a case study of leptospirosis

Step selection functions are a useful tool for analysing fine-scale human movements to understand environmental interactions in the context of infectious disease epidemiology.
eLife

E(spl)m4 Directly Antagonizes Traf4 to Inhibit JNK Signaling in Drosophila

The authors identify the Bearded-type small protein E(spl)m4 as a physical and genetic interactor of TRAF4 in the Drosophila wing disc. These valuable findings with potential biomedical relevance are, ...
eLife

Determining fragility and robustness to missing data in binary outcome meta-analyses, illustrated with conflicting associations between vitamin D and cancer mortality

This manuscript makes a valuable contribution to the concept of fragility of meta-analyses via the so-called 'ellipse of insignificance for meta-analyses' (EOIMETA). The strength of evidence is solid, ...
eLife

Sensitivity of the human temporal voice areas to nonhuman primate vocalizations

This valuable study shows that regions of the human auditory cortex that respond strongly to voices are also sensitive to vocalizations from closely related primate species. The study is ...
eLife

Ubiquitous predictive processing in the spectral domain of sensory cortex

The authors analyzed spectral properties of neural activity recorded using laminar probes while mice engaged in a global/local visual oddball paradigm. They found solid evidence for an increase in ...
eLife

TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

This study presents a valuable tool named TSvelo, a computational framework for RNA velocity inference that models transcriptional regulation and gene-specific splicing. The evidence supporting the ...
eLife

Endogenous corazonin signaling modulates the post-mating switch in behavior and physiology in females of the brown planthopper and Drosophila

Mating in insects commonly induces an alteration in behavior and physiology in the female that ensures optimal offspring. This is referred to as a post-mating response (PMR). The induction of a PMR ...
eLife

An interneuronal CRH and CRHBP circuit stabilizes birdsong performance

The performance of skilled behaviors requires a balance between consistency and adaptability. Although the neural mechanisms that regulate this balance have been extensively studied at systems and ...
eLife

Increased layer 5 Martinotti cell excitation reduces pyramidal cell population plasticity and improves learned motor execution

This valuable study addresses a critical and timely question regarding the role of a subpopulation of cortical interneurons (Chrna2-expressing Martinotti cells) in motor learning and cortical dynamics ...
eLife

The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation

The enteric bacterial Shigella secretes a virulence factor that degrades the pivotal human defense protein RNF213, thereby protecting cytosolic bacteria from interferon-driven ubiquitylation and ...
eLife

Center-surround inhibition in expectation and its underlying computational and artificial neural network models

Expectation optimizes perception through center-surround inhibition, enhancing expected representations while suppressing similar, irrelevant ones.
eLife

Microbiology and Infectious Disease

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