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The three best characterized Wnt signaling pathways are the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway.

This review explores the molecular mechanisms underlying Wnt pathway activation, highlighting its critical components and examining upstream factors that may influence its function. Additionally, the …

Wnt proteins are highly conserved in evolution and are active in every branch of the animal kingdom. Wnt signaling is often implicated in stem cell control, as a proliferative and self-renewal signal.

Jan 3, 2022 · In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research.

The Wnt signaling pathway is defined as a protein signaling mechanism that regulates gene expression, cell proliferation, and differentiation, particularly through the activation of the Wnt/beta-catenin pathway.

May 14, 2013 · Wnt signaling regulates normal embryonic development, tissue homeostasis, and regeneration, and the pathway is highly conserved throughout evolution. Aberrations of Wnt signaling …

In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the …

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis …

Feb 19, 2024 · Here, we review the origin and evolution of the Wnt pathway and its molecular components. We first provide a brief overview of canonical and non-canonical Wnt signalling …