About Sickle Cell Disease
About Sickle Cell Disease
May 26, 2020
genome.gov
Sickle Cell Disease - Hematology - Merck Manual Professional Edition
Sickle Cell Disease - Hematology - Merck Manual Professional Edition
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🔔 Follow Save this for revision 📌 Share with your study buddy 💬🧠 Sickle cell anemia is an autosomal recessive hemoglobinopathy with HbS polymerization in low oxygen. ➤ 🧪 Suspect hemolysis: ↑ reticulocytes, ↑ LDH, ↑ indirect bilirubin, ↓ haptoglobin ➤ 🔬 Smear clue: sickled cells ± target cells ➤ ✅ Confirmatory test: Hemoglobin electrophoresis / HPLC (HbS present; HbA absent in HbSS) ➤ ⚡ Vaso-occlusive crisis: severe bone pain; dehydration/hypoxia triggers ➤ 👶 Dactylitis: classic early pres
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